Abstract
Commander complex is a 16-protein complex that plays multiple roles in various intracellular events in endosomal cargo and in the regulation of cell homeostasis, cell cycle and immune response. It consists of COMMD1–10, CCDC22, CCDC93, DENND10, VPS26C, VPS29, and VPS35L. These proteins are expressed ubiquitously in the human body, and they have been linked to diseases including Wilson’s disease, atherosclerosis, and several types of cancer. In this review we describe the function of the commander complex in endosomal cargo and summarize the individual known roles of COMMD proteins in cell signaling and cancer. It becomes evident that commander complex might be a much more important player in intracellular regulation than we currently understand, and more systematic research on the role of commander complex is required.
Highlights
Multifaceted Operator in IntracellularCellular homeostasis maintenance in a trans-Golgi network is necessary for every aspect of cellular life including cell growth, cell cycle, cell death, various signal transduction pathways, and immune response [1,2,3]
Commander complex consists of ten commander proteins (COMMD1–10), coiled-coil domain containing proteins CCDC22 and
We describe the function of commander complex in the endosomal cargo and summarize the known functions of individual COMMD proteins in the regulation of cell homeostasis regulating immune response, signal transduction and cell cycle
Summary
Cellular homeostasis maintenance in a trans-Golgi network is necessary for every aspect of cellular life including cell growth, cell cycle, cell death, various signal transduction pathways, and immune response [1,2,3]. We describe the function of commander complex in the endosomal cargo and summarize the known functions of individual COMMD proteins in the regulation of cell homeostasis regulating immune response, signal transduction and cell cycle. Most of the reported roles of COMMD proteins are very recent individual discoveries, indicating that many important observations on this complex are still unmade. These will further underline the importance of the Commander complex and expand the already known diverse functions and roles of the complex
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