Abstract
The BRCA1 and BRCA2 genes are the two most commonly mutated in hereditary breast and ovarian cancer, and they are the canonical pair when it comes to cancer testing. [...]
Highlights
The current model of delivering genetic testing for the BRCA genes in North America dates to the mid-1990s, at a time when genetic testing was expensive and the clinical benefits were largely unproven
We propose offering genetic testing for BRCA1 and BRCA2 to all women and men who wish to be tested, using an Internet-based system
Face-to-face genetic counselling could be limited to the small percentage of women who are identified as mutation carriers
Summary
The current model of delivering genetic testing for the BRCA genes in North America dates to the mid-1990s, at a time when genetic testing was expensive and the clinical benefits were largely unproven. Because of the high cost, public and private insurers were not willing to pay for testing for all comers. A women is referred by her physician to a specialized cancer genetics clinic, where a formal assessment is conducted.
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