Abstract
The clinical effectiveness of ultraviolet light (UV) disinfection remains unclear. This study aimed to investigate the effect of adding pulsed xenon UV (PX-UV) disinfection to the terminal cleaning protocol on the rate of methicillin-resistant Staphylococcus aureus (MRSA) acquisition at a Japanese hospital. The use of a PX-UV disinfection device was added to the manual terminal cleaning protocol applied after the discharge or transfer of patients treated in the intensive and high care units. We used a Poisson regression model to examine the incidence of MRSA acquisition, based on the study period, PX-UV intervention status, unit type, and the rate of consumption of alcohol-based hand rub (ABHR). Approximately 86% of the rooms in the intervention units were terminally disinfected with the PX-UV device. In the intervention units, the incidence of MRSA acquisition decreased from 3.56 per 1,000 patient-days in the nonintervention period to 2.21 per 1,000 patient-days in the intervention period. Moreover, the use of PX-UV disinfection decreased the risk of MRSA acquisition (incident rate ratio: 0.556; 95% confidence interval, 0.309-0.999; P = .0497). ABHR consumption did not affect the risk of MRSA acquisition. Adding PX-UV disinfection to terminal manual cleaning reduced the rate of MRSA acquisition.
Highlights
The clinical effectiveness of ultraviolet light (UV) disinfection remains unclear
A recent systematic review reported that the pulsed xenon UV (PX-UV) disinfection method was associated with a significantly reduced rate of C. difficile infection (CDI), and methicillin-resistant Staphylococcus aureus (MRSA) infections (IRR: 0.79, 95% CI: 0.64-0.98).[11]
In 5.4% of the rooms, PX-UV disinfection was not completed for the required number of cycles according to the protocol, and in 8.9% of the rooms, PX-UV disinfection was Before intervention March 2018 to February 2019
Summary
The clinical effectiveness of ultraviolet light (UV) disinfection remains unclear. This study aimed to investigate the effect of adding pulsed xenon UV (PX-UV) disinfection to the terminal cleaning protocol on the rate of methicillin-resistant Staphylococcus aureus (MRSA) acquisition at a Japanese hospital. (200-280 nm), a small portion of UV-B spectrum, and the visible light spectrum at a pulsed frequency.[7] Several studies have demonstrated that the use of PX-UV disinfection method reduced the microbial contamination in the environment.[7,8,9,10] In addition, a recent systematic review reported that the PX-UV disinfection method was associated with a significantly reduced rate of C. difficile infection (CDI) (incidence rate ratio [IRR]: 0.73, 95% confidence interval [CI]: 0.57-0.94), and methicillin-resistant Staphylococcus aureus (MRSA) infections (IRR: 0.79, 95% CI: 0.64-0.98).[11] the quality of evidence is low, and the effect of PX-UV disinfection method on reducing the rate of healthcare-associated acquisition of multidrug-resistant organisms and C. difficile remains controversial
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