Abstract

The vertebrate taste bud contains 50 to 150 spindle-shaped cells assembled in an onion-shaped structure approximately 60 μm wide and 80-100 μm tall. Located on the tongue and other portions of the oral epithelium, taste buds are always in a state of flux, with new cells continually entering the bud and moving from the periphery to the core as they mature. During the developmental process, young taste cells form afferent synaptic connections with sensory nerve fibers which enter the taste bud at the base and course tortuously throughout the bud. As taste cells age and become senescent, they lose their synaptic connections with the nerve fibers, degenerate, and eventually disappear. All of the processes described above result in the complete turnover of the cells within a taste bud in a period of from 10 days to two weeks in the rat.

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