Abstract
Cellulose and cyclodextrins possess unique properties that can be tailored, combined, and used in a considerable number of applications, including textiles, coatings, sensors, and drug delivery systems. Successfully structuring and applying cellulose and cyclodextrins conjugates requires a deep understanding of the relation between structural, and soft matter behavior, materials, energy, and function. This review focuses on the key advances in developing materials based on these conjugates. Relevant aspects regarding structural variations, methods of synthesis, processing and functionalization, and corresponding supramolecular properties are presented. The use of cellulose/cyclodextrin conjugates as intelligent platforms for applications in materials science and pharmaceutical technology is also outlined, focusing on drug delivery, textiles, and sensors.
Highlights
INTRODUCTIONCyclodextrins (CDs) and cellulose are fascinating molecules with synergistic properties that have been critical for preparing new derivatives directed at several innovative applications, ranging from textiles (El Ghoul et al, 2016; Mihailiasa et al, 2016) coatings (Huang et al, 2013; Shah et al, 2015; Mihailiasa et al, 2016; Umoren and Eduok, 2016; Jimenez et al, 2017), sensors (Qiu and Hu, 2013) and paper making to pharmaceutical technology (Siepmann and Peppas, 2001; Hadjichristidis et al, 2003; Zhang et al, 2012; Shokri and Adibkia, 2013; Yang and Yang, 2013; Mogosanu and Grumezescu, 2015; Thakur, 2015; Lalatsa and Barbu, 2016; Jawaid and Mohammad, 2017; Nishio et al, 2017; Yadav et al, 2018)
In this type of structures, CDs can be covalently attached to the surface of cellulose so that the cavity of the former is accessible to the guest molecules
A relevant outcome is the number of works focused on the combination of cellulose derivatives and supramolecular macrocycles such as CDs which are protected by ca. 75 patents
Summary
Cyclodextrins (CDs) and cellulose are fascinating molecules with synergistic properties that have been critical for preparing new derivatives directed at several innovative applications, ranging from textiles (El Ghoul et al, 2016; Mihailiasa et al, 2016) coatings (Huang et al, 2013; Shah et al, 2015; Mihailiasa et al, 2016; Umoren and Eduok, 2016; Jimenez et al, 2017), sensors (Qiu and Hu, 2013) and paper making to pharmaceutical technology (Siepmann and Peppas, 2001; Hadjichristidis et al, 2003; Zhang et al, 2012; Shokri and Adibkia, 2013; Yang and Yang, 2013; Mogosanu and Grumezescu, 2015; Thakur, 2015; Lalatsa and Barbu, 2016; Jawaid and Mohammad, 2017; Nishio et al, 2017; Yadav et al, 2018). The relevant advances on the methods of preparation, characterization and application of functional structures involving cyclodextrin and cellulose derivatives, have been described in an uncorrelated manner in the current state of the art, being summarized in references (Du et al, 2012; Qiu and Hu, 2013; Yang and Yang, 2013; Liu et al, 2015a; Mogosanu and Grumezescu, 2015; Nafee et al, 2015; Higashi et al, 2016; Lalatsa and Barbu, 2016). A relevant outcome is the number of works focused on the combination of cellulose derivatives and supramolecular macrocycles such as CDs which are protected by ca. 75 patents (data retrieved from Web of Science and Espacenet, EPO, databases)
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