Abstract
Introduction: National Early Warning Score (NEWS) is able to evaluate the integral stress level and function status of the body through vital signs, TnI and NTproBNP can reflect the degree of myocardial injury and cardiac function to a certain extent. Whereas, there is no study working on the estimate value of the combined index of NEWS and TnI or NTproBNP in patients with cardiovascular disease so far. We assumed that the combined index was more strongly associated with prognosis compared to NEWS alone. Method: This was a prospective observational cohort study of adult admissions to emergency department with the diagnosis of cardiovascular disease. NEWS was calculated respectively and combined with TnI and NTproBNP in multivariable logistic regression models. The primary outcome was 30-day mortality after ED arrival, capturing all patients with cardiac arrest at our institution. Result: All of 221 cases were followed up in 30 days, the mortality in 30-day was 19.5% (43/221). 56 patients (25.3%) died or were admitted to ICU within 48h of ED admission. The area under receiver operator characteristic curve (AUROC) of combined index as NT, NP, NTP for 30d mortality were higher than NEWS alone (0.75, 0.77, 0.79 vs 0.67, p<0.05 respectively). The predictive value of NT, NTP were superior to the NEWS alone (AUROC: 0.76, 0.78 vs 0.67; p<0.05). Conclusion: Combined indexes showed better able to predict values for 30-day mortality than the NEWS alone in cardiovascular disease. The combinations of NT, NTP also had better evaluating ability for ICU admission and mortality in 48 hours than NEWS
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call