Abstract
tire pathway components. In the absence of specific antibody to activate the classical pathway, this impairment of the alternative pathway may well prejudice the newborn infant's early response to infection. Previous reports of low serum IgG concentrations were not substantiated. Comparison O f the total protein and serum albumin concentrations demonstrates the ability of SGA newborn infant to maintain normal values despite the inability of the maternoplacental supply line to transfer sufficient substrate to permit optimal fetal growth. In this respect the SGA neonate resembles the marasmic child, whose serum protein and complement values are well preserved in comparison with those in kwashiorkor? .... With the exception of lower C3 levels, we have not demonstrated any significant impairments in the complement system and immunoglobulin concentrations of term SGA infants relative to AGA controls. If there are more infections among these infants, these aspects of humoral immunity do not appear to be implicated to a major degree.
Published Version
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