Abstract
Efforts to assess and quantify deleterious effects at low exposure levels are directed mainly towards radiation as a single isolated agent, and rarely towards the concomitant presence of other natural and anthropogenic toxicants. Only these combined exposures may lead to observable health risk effects. In addition, they might differ from those expected from simple addition of the individual risks due to interaction. The existing database on combined effects is rudimentary, mainly descriptive, and rarely covers exposure ranges large enough to make direct inferences to present-day low dose exposure situations. Therefore, any risk assessment will have to consider the question whether combined effects, i.e., interaction between two or more agents, will influence the health outcome from specific exposure situations in such a way that predictions derived from simple standard exposure situations would have to be revised. An experimental approach is described to investigate the combined action of γ-radiation and arsenic.
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