Combined effects of alcohol and lead on cerebrospinal fluid production

Abstract

Currently, due to the development of industry, a high incidence of heavy metal salt poisoning is observed, especially in people with alcohol dependence. The study aims to investigate the combined effects of these pathogens on the central nervous system. The study demonstrates changes in intracranial pressure and cerebrospinal fluid production in isolated and combined poisoning of lead and ethanol based on experimental models on 10 and 40 days of exposure, 3 main groups were formed – the group of lead salts, ethanol, combined intoxication, after which the main indicators were measured. The effect of separate and combined action of alcohol and lead on cerebrospinal fluid production and haemodynamic indices in experimental animals was studied. It was found at 40-day intoxication indices remained above normal, systemic arterial pressure was 131.8 mmHg, and the rate of cerebrospinal fluid production was 0.073±0.002 ml/min. Combined 10-day combined action of alcohol and lead enhances their excitatory effect, which is characterised by an increase in systemic arterial pressure (to the level of 135.6 mmHg) and general psycho-somatic agitation, the rate of cerebrospinal fluid production was 0.077±0.008 ml/min. The 40-day co-exposure manifested mainly toxic effects of lead, as shown by a decrease in cerebrospinal fluid production of 0.049±0.001 ml/min, and a decrease in blood pressure to a level of 93.6 mmHg. The results of this study will make it possible to develop treatment protocols for patients with ethanol and heavy metal salt poisoning, especially in the field of anti-oedema therapy