Abstract
The simultaneous analysis of expression data from multiple species reveals a core set of conserved cycling genes that is much larger than previously thought.
Highlights
Global transcript levels throughout the cell cycle have been characterized using microarrays in several species
Combined analysis of cell cycle expression data We developed an algorithm for combining sequence and expression data in order to identify cycling genes [12]
Orc1 is the largest subunit of the origin recognition complex (ORC), which binds to replication origins and triggers the assembly of pre-replication complexes (pre-RCs) [47]. (e) TOG related proteins, a family of microtubule-associated proteins (MAPs)
Summary
Global transcript levels throughout the cell cycle have been characterized using microarrays in several species Analysis of these experiments focused on individual species. Global transcript levels throughout the cell cycle have been characterized using microarray expression data in several species These include humans [1], budding and fission yeast [2,3,4,5,6], plants [7], and bacteria [8]. Hundreds of genes have been identified whose transcripts oscillate during the cell cycle, and in budding yeast it is estimated that 15% of all genes are subject to this type of control Despite this large cross-species effort, a number of studies have concluded that a surprisingly small number of genes conserved in two or more species are periodically transcribed in these species. All three studies concluded that periodicity at the transcript level was conserved across species in only a small number of cases
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