Abstract
Recently, the efficiency of anticancer therapeutics is increasingly measured by their potential to eliminate a subpopulation of tumor cells, the so called tumorigenic stem cells (TSC). Also in medulloblastoma (MB), the most malignant embryonal brain tumor, such TSC were identified by expression of CD133 or CD15. In previous studies we could show a radioadditive effect of the demethylating agent 5-aza-2'deoxycytidin (5-aza-dC) on the clonogenic survival of human MB cells. Now we aim to clarify whether 5-aza-dC and irradiation (IR) have similar effects on the TSC subpopulation. In addition we applied resveratrol (RV), to see if combination of above treatments with this differentiation inducer may further reduce the clonogenic potential of MB cells.
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