Combination of Sodium Hyaluronate, Withania Somnifera Extract and Niacinamide Improves Hydration and Skin Tone – A Clinical Study

Abstract

Background: Multiple moisturizing solutions with sodium hyaluronate, Withania sominifera, and niacinamide are commercially popular. Detailed clinical studies portraying their activity are not available. Objective: This study aims to study the clinical efficacy of a phyto-bioactive cream in improving skin hydration and tone with 4 weeks of continuous usage. Methodology: We conducted a non-comparative, single-blind study on 50 Asian female volunteers with Fitzpatrick skin types III and IV for 28 days. Cosmetic acceptability and safety of the product were established via self-evaluation questionnaires. The ability of the topical formulation in maintaining skin tone, hydration, and firmness was determined by instrumental analysis and smoothness by dermatologist evaluation. Results: A total of 46 subjects completed the study. High levels of skin hydration were noted instantaneously (+61.11%) and post continuous use of the product. Significant reduction in the appearance of age/dark spots (ITA°), Δ ITA°= 37.49% and increase in skin lightness (L) by 2.66% compared to baseline was observed in 4 weeks. More than 80% of the subjects reported an increase in skin firmness and smoothness in 4 weeks of twice-a-day product usage. Conclusion: Our study establishes the safety and acceptability of the phyto-bioactive cream. The efficiency of the combination of Withania somnifera extract, sodium hyaluronate, and niacinamide in improving skin hydration and tone has been proven.