Abstract
Objective: The objective of the study was to investigate the effect of leptin analog and salbutamol in obese asthmatic mice.
 Methods: Obese asthmatic condition was induced by administration of hypercaloric diet for 8 weeks followed by ovalbumin-aluminum hydroxide. The animals were treated with leptin analog (0.4 mg/kg, i.p. for 14 days) and salbutamol (2 mg/kg, PO for 14 days). Biochemical parameters such as serum leptin, ghrelin, and tumor necrosis factor-α and physical parameters such as tidal volume and airflow rate were estimated to confirm the state of asthma and obesity, respectively.
 Results: Elevated serum leptin and ghrelin were associated with leptin resistance in obese asthmatic mice. It was found that a significant increase in serum leptin level with animal treated with leptin analog and salbutamol when compared to animals treated with leptin analog alone. The result of respiratory parameters and serum parameters also improved with the combination of leptin analog and salbutamol. From our study, we found that salbutamol potentiates the effect of leptin analog in obese asthmatic condition.
 Conclusion: Leptin analog and salbutamol are an alternative treatment approach to treat the obese asthmatic condition.
Highlights
Obesity is linked to the imbalance between energy expenditures [1]
It was observed that airflow rate was significantly increased in leptin analog treated an obese asthmatic animal (OB-AS-L), salbutamol treated an obese asthmatic animal (OB-AS-S), and leptin analog with salbutamol treated an obese asthmatic animal (OB-AS-L-S) when compared to an obese asthmatic animal (OB-AS) (Group I, *p
Airflow rate was elevated in leptin analog with salbutamol treated obese asthmatic animals (OB-AS-L-S) when compared to leptin analog treated an obese asthmatic animal (OB-AS-L) (Group II, @ p
Summary
Obesity is linked to the imbalance between energy expenditures [1]. It is due to excessive food intake with inactive lifestyle [2,3,4]. Obesity is one of the vital factors to worldwide for the burden of chronic sickness and disabilities. According to reports [5,6], over 1000 million adults worldwide are morbidly obese while of 300 million of them are clinically obese. Multiple factors contribute to the etiology are sedentary lifestyle, lack of physical activity and consumption of high energy-rich diet. The various study revealed that overall 20% men and 30% of females are obese worldwide [7]. The epidemic of obesity is becoming a universal problem, imposing considerable freight on the individual and society rising morbidity and mortality [8]
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