Abstract
Antifungal activity of three nagilactones isolated from the root bark of Podocarpus nagi (Podocarpaceae), alone and in combination with a variety of phenylpropanoids, was investigated against three fungi, Candida albicans, Saccharomyces cerevisiae, and Pityrosporum ovale. Nagilactone E [2], the most abundant norditerpene dilactone, showed moderate to weak activity against these fungi. This activity was dramatically enhanced by several naturally occurring phenylpropanoids such as anethole [5] and isosafrole. For example, anethole enhanced the activity of nagilactone E as much as 128-fold for C. albicans, decreasing the MIC of this nagilactone from 800 to 6.25 micrograms/ml.
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