Abstract
Background and Aims: Intimal hyperplasia refers to proliferation and migration of vascular smooth muscle cells primarily in the tunica intima, resulting in arterial wall thickening and decreased arterial lumen size. Neointimal hyperplasia is the major cause of restenosis after percutaneous carotid interventions such as stenting or angioplasty. The aim of this study was to investigate the effect of Photodynamic therapy and catheter- based 90Y- mediated β- brachytherapy on cerebrovascular neointimal hyperplasia in a prospective animal cohort study, wherein diagnostic B- mode ultrasound is combined with therapy system, with a goal of increased safety.
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