Abstract
The simple and available technique of colorimetry and indirect X-ray fluorescence determination of tetracycline hydrochloride (in the form of colored complex with iron(III) ions) and cyanocobalamine (in the form of the colored thiocyanate complex with cobalt(II) ions) is offered. The analytes were separated from the accompanying components by sorption to polyurethane foam based on ethers. The conditions of sorption separation and measurement of analytical signal of these substances are optimized. The obtained results of tetracycline drugs and injection solution B12 vitamin are in satisfactory agreement with data declared by the manufacturer.
Highlights
One of the important tasks of pharmaceutical chemistry is the development of effective ways of determination of active ingredients in drugs
The development of technically simple and selective approaches of determination of active ingredients in drugs is an actual task of modern pharmaceutical chemistry
The colorimetry techniques are widely used in analytical chemistry, but combination of these techniques with digital processing of the received images allows to expand method scopes and to improve metrological characteristics [5]
Summary
One of the important tasks of pharmaceutical chemistry is the development of effective ways of determination of active ingredients in drugs. Low selectivity is one of the main disadvantages of chemical methods, but the high cost of instrumental methods and requirements to the qualification of the operator limited its available for field laboratories and drugstores. In this regard, the development of technically simple and selective approaches of determination of active ingredients in drugs is an actual task of modern pharmaceutical chemistry. Visual colorimetry is among simple and available methods of analysis. The colorimetry techniques are widely used in analytical chemistry, but combination of these techniques with digital processing of the received images allows to expand method scopes and to improve metrological characteristics [5]
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