Abstract
A colorimetric method for the analysis of escitalopram oxalate in pure form and in tablets has been developed based on the formation of chloroform soluble ion associates with bromocresol green acidic dye. The extract of ion associates exhibited absorption maxima at 417 nm obeying Beer's law in the range of 2-10 µg/ml. The method is simple, precise and accurate with recovery of 98-102% and does not require any separation of soluble excipients from tablet dosage form.
Highlights
A colorimetric method for the analysis of escitalopram oxalate in pure form and in tablets has been developed based on the formation of chloroform soluble ion associates with bromocresol green acidic dye
HPLC[3-8] methods were reported for the estimation of escitalopram oxalate in biological fluids
Escitalopram oxalate contains a tertiary amino group in its side chain, which readily complexes with an anionic species, bromocresol green (BCG) in chloroform and the neutral pair complex produced with λmax 417 nm was measured spectrophotometrically
Summary
Colorimetric Method for the Estimation of Escitalopram Oxalate in Tablet Dosage Form Vetrichelvan, et al.: Colorimetric Method for the Estimation of Escitalopram A colorimetric method for the analysis of escitalopram oxalate in pure form and in tablets has been developed based on the formation of chloroform soluble ion associates with bromocresol green acidic dye.
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