Abstract
The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.
Highlights
Collagen is an abundant protein found in the human body existing in bones, tendons, muscles and skin [1]
Collagen-based biomaterials are extremely important for regenerative medicine and tissue engineering (TE)
Enhancement of mechanical strength, biodegradability and delivery characteristics support the optimization of biomaterials based on collagen for biomedical applications [95]
Summary
Collagen is an abundant protein found in the human body existing in bones, tendons, muscles and skin [1]. Polymeric NPs possess reduced cytotoxicity, high permeation and retention (EPR) effect, good biocompatibility and are able to deliver drugs which are poorly soluble and control their release They retain bioactivity of bioactive compounds from degradation of enzymes which makes them suitable to overcome problems in tissue engineering and regenerative medicine (TERM) applications [20,26]. Collagen NPs are advantageous over other natural and synthetic polymeric NPs as they have favourable biocompatibility and biodegradability, low antigenicity, high contact surface, reduced toxicity and high cationic-charge density potential as they possess many amino groups; in the absence of surface modification with target compounds, they have a restricted capacity to cross the blood brain barrier They are small sized, have large surface area and absorptive capability and the ability to diffuse in water to form colloidal solutions. This review will discuss the examples of collagen enhancing the properties of NPs, their chemical and physical preparatory methods and various developments and applications of these collagen NPs in DDS and TE
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
