Impact of Nanoparticulate Drug Delivery System of Herbal Drug in Control of Diabetes Mellitus

Abstract

Aim: The main objective of the current study is to organize and evaluate polymeric nanoparticles for the selected drug Gymnemic acid, improve the bioavailability of poorly bioavailable gymnemic acid, enhance the anti-diabetic activity of Gymnemic acid, reduce the dose size of Gymnemic acid by reducing the particle size. Method and procedure: Gymnemic acid nanoparticles was prepared through emulsion-droplet coalescence method, by using chitosan polymer (GNP1-GNP5). Based on the invitro drug release profile of Gymnemic acid nanoparticles formulations (GNP1-GNP5) formulation GNP3 is selected as the best preparation in which the particle size was 195 nm[1]. Since from ancient times the naturopathic treatment for diseases has been explored widely and in advance momentum in the present situation, and has several pharmacological significance. Nano particulate drug delivery systems symbolize a promising drug delivery system[2] in recent years for its prescribed and targeted drug release. They exists as with a size choice of 10-1000nm, in which the drug or dissolved active ingredient, encapsulated, entrapped, absorbed or attached to the matrix system. The present research is a development of nanoparticulate[3,4] drug delivery system for Gymnema sylvestre by ionic gelation method. The formulation is characterized by particle size, zeta potential, particle morphology and best formulation was selected for the further studies. Result: The Gymnemic acid nanoparticles [1] were formulated and evaluated for its invitro drug release profile. The results showed that the in vitro drug release for GNP1, GNP2, GNP3, GNP4 and GNP5 were found 99.55± 0.89, 99.51± 0.34, 99.57± 0.31,78.82± 0.82 and 65.73± 0.62 respectively at the end of 24hrs. Conclusion: It can be concluded that the newly formulated controlled release nanoparticulate drug delivery[32] systems of Gymnemic acid may be ideal and effective in the treatment of diabetes mellitus by allowing the drug to release continuously for 24 hrs.