Abstract
Multidrug resistant bacteria have become a significant cause of morbidity and mortality worldwide. Resistance to last resort antibiotics such as: colistin, newer generation cephalosporins is one of the most important current public health problems. Escherichia coli is the member of the normal microbiota of the human intestine and the intestinal and extra-intestinal pathogenic strains. Treating E. coli infection become difficult because of their resistance to different antibiotics, even to last resort antibiotics. The present study aimed to investigate the phenotypic and genotypic resistance against colistin in 181 extended-Spectrum β-Lactamase (ESBL) producing E. coli isolated from healhthy people and clinical specimens, (28 from healthy people, 153 from clinical specimens). The results showed: Out of 181 E. coli isolates, 13 (7.2%) were identified as colistin resistant phenotype in which 3.6% isolates from healthy people and 0.65% from clinical specimens was positive for the mcr-1 gene. Non of the ESBL producing E.coli isolates had the mcr-3 or mcr-5 genes.
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