Abstract
Colistin-Resistant Enterobacteriaceae Carrying the mcr-1 Gene among Patients in Hong Kong.
Highlights
During December 8, 2015–January 8, 2016, we conducted prospective laboratory surveillance of mcr-1–carrying Enterobacteriaceae and Acinetobacter species in a universityaffiliated tertiary hospital serving a population of ≈0.53 million in Hong Kong, China
The range of colistin MICs of the 5 mcr-1–positive isolates was 3–64 μg/mL; all were susceptible to carbapenem
Finding the mcr-1 gene in 0.4% of Enterobacteriaceae clinical isolates in Hong Kong is expected because of the high proportion of livestock and meat imported from China, where prevalence of colistin-resistant isolates is up to 25.4% and 28.0% in pigs and retail chicken meat, respectively [5,6]
Summary
The discovery of the plasmid-mediated colistin-resistant gene mcr-1 in Escherichia coli [1] raises concern in the medical community because colistin might be useless in treating infections caused by mcr-1–carrying Enterobacteriaceae. During December 8, 2015–January 8, 2016, we conducted prospective laboratory surveillance of mcr-1–carrying Enterobacteriaceae and Acinetobacter species in a universityaffiliated tertiary hospital serving a population of ≈0.53 million in Hong Kong, China. Of the 5 mcr-1–positive isolates, 2 were from blood cultures from patients with biliary tract infection, 1 from a mid-stream urine specimen from a patient with symptomatic urinary tract infection, and 2 from stool specimens from asymptomatic patients.
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