Abstract
Background: Hepatic steatosis is an increasingly prevalent problem in liver transplantation (LT) leading to increased cold ischemia and reperfusion (CIR) injury and severe allograft dysfunction. Hepatic steatosis is strongly associated with endoplasmic reticulum (ER) stress which can trigger cell death via multiple pathways. We hypothesized that acute ER stress gene expression following CIR injury may mediate injury in steatotic livers following liver transplantation. Methods: Steatotic livers from obese Zucker rats were transplanted into lean recipients (cold preservation-2hours, reperfusion-12hr) (n=5).
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