Abstract
Chronic exposure of rats to mild cold (5°C) resulted in a significant elevation of blood pressure (BP) within 4 days. Peripheral administration of losartan (AT 1 receptor antagonist) could decrease the elevated BP to the control level. AT 1 receptor mRNA was significantly increased in resistance arteries by exposure to cold. Chronic exposure to cold was accompanied by diuresis and a decrease in urine osmolality. The circulating level of arginine vasopressin (AVP) was not affected significantly by cold exposure. It is concluded that cold-induced hypertension may be maintained by up-regulation of AT 1 receptors. Cold-induced diuresis may be due to decreased renal responsiveness to AVP rather than inhibition of AVP release.
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