Colchicine resistance: Associated factors and its effect on health-related quality of life in patients with familial Mediterranean fever.

Abstract

To determine the factors associated with colchicine resistance and the effect of colchicine resistance on health-related quality of life (QoL) in patients with familial Mediterranean fever (FMF). Demographic and clinical features, MEFV gene mutations, and Pras disease severity scores were recorded. QoL was assessed using the Short Form-36 (SF-36) and FMF-QoL scales. Colchicine resistance was defined as at least 1 attack per month for 6months at the maximum tolerated dose of colchicine in fully compliant patients. The mean age of 118 patients (90 female, 28 male) with FMF was 38.4 ± 12.5 years. The percentage of colchicine-resistant patients was 19.5%. In univariable analysis, smoking (odds ratio [OR]=2.885; 95% confidence interval [CI]=1.104-7.539; P=0.031), attack duration (OR=1.955; 95% CI=1.137-3.360; P=0.015), presence of arthritis (OR=5.235; 95% CI=1.508-18.179; P=0.009), and disease severity score (OR=1.790; 95% CI=1.334-2.402; P < 0.001) were associated with colchicine resistance. The FMF-QoL and subscales of SF-36 except for role emotional and vitality, were different between colchicine-resistant and non-resistant patients (P < 0.05). Smoking, attack duration, presence of arthritis, and disease severity were associated with colchicine resistance in fully compliant FMF patients. Colchicine-resistant patients had poorer health-related QoL.