Abstract
In recent years, hydrogen peroxide and nitrous oxide (1) "green oxidants" – have attracted much attention of researchers as a selective oxidizing agent for the catalytic oxidation of pyridine bases. In this regard, the reaction of pyridine oxidation by hydrogen peroxide and nitrous oxide under homogeneous conditions, in the gas phase, without the use of catalysts, at atmospheric pressure, has been experimentally investigated. Areas of selective oxidation of pyridine with hydrogen peroxide and nitrous oxide have been established, and optimal conditions have been found for obtaining valuable raw materials required in the petrochemical, chemical, and pharmaceutical industries
Highlights
The development of fundamentally new methods for the oxidation of pyridine bases based on cheap and affordable raw materials is one of the most important areas in the field of small chemistry
In usual conditions 2-hydroxypyridine is in balance with zwitterion form: In connection with oxidation of P by aqueous solution of hydrogen peroxide proceeds in gaseous phase, most probably, P entering first the reaction zone in the gaseous state oxidizes to 2-hydroxypyridine (A), but at an outlet from it having been annealed in the zone of annealing transforms into ketoform – 2-pyridon (B): N O Н
This transitional state dissociates into two stable substances (2.2-ODP and water) and more active radical ∙OH It is known [6, 7] that if in the process of radical reaction there are formed two end substances and free radical, the latter may be more active, than an initial one. It follows from the suggested scheme of P oxidation, as well the data [6, 7], that interaction of two complicated gross reactions by mechanism of chemical conjugation is in its base: rate of the active centers – of atomic oxygen under thermal decomposition of nitrous oxide (1)
Summary
The development of fundamentally new methods for the oxidation of pyridine bases based on cheap and affordable raw materials is one of the most important areas in the field of small chemistry. The creation of innovative technologies for the selective synthesis of practically important precursors for the pharmaceutical industry is relevant. In this regard, the implementation of oxidation reactions of pyridine bases using H2O2 and N2O without special catalysts at atmospheric pressure, using simplified technology, is promising. New oxidation reactions of pyridine with a green oxidizer , H2O2 and N2O in the gas phase were studied. The qualitative determination of the reaction products composition was performed by chromatomass-spectroscopic method: [GCMS (trace GC ultra/ Trace DSQ USA]) and Agilent Technologies (Germany)
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