Abstract
The effect of oxcarbazepine compared to standard antiepileptic drug therapy (carbamazepine and valproate) on cognitive function in 112 children and adolescents (ages 6 to 16 years) with newly diagnosed partial seizures was investigated in a multicenter, open-label, randomized, active-control group study at University Hospital, Bern, Switzerland; University of Maastricht, The Netherlands; and other European centers.
Highlights
The effect of oxcarbazepine compared to standard antiepileptic drug therapy on cognitive function in 112 children and adolescents with newly diagnosed partial seizures was investigated in a multicenter, openlabel, randomized, active-control group study at University Hospital, Bern, Switzerland; University of Maastricht, The Netherlands; and other European centers
Mean Computerized Visual Searching Task (CVST) times decreased in all 3 treatment groups compared to baseline, indicating improvement
Patients were free of seizures in 58% of oxcarbazepine-treated and in 50% of those receiving carbamazepine/valproate
Summary
The effect of oxcarbazepine compared to standard antiepileptic drug therapy (carbamazepine and valproate) on cognitive function in 112 children and adolescents (ages 6 to 16 years) with newly diagnosed partial seizures was investigated in a multicenter, openlabel, randomized, active-control group study at University Hospital, Bern, Switzerland; University of Maastricht, The Netherlands; and other European centers. Mean daily doses during the 4 weeks prior to cognitive function testing after 6 months treatment were 19.6 mg/kg for oxcarbazepine, 14.4 mg/kg for carbamazepine, and 20.7 mg/kg for valproate.
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