Abstract
Ovarian squamous cell carcinoma is a rare malignancy and the occurrence is attributable to malignant transformation of an existing ovarian dermoid cyst. The de novo occurrence of squamous cell carcinoma of the ovary, in the absence of an antecedent ovarian dermoid, is extremely rare. A 40- years- old female presented with pain and enlargement of abdomen since last 4 months. A mass was felt over right iliac fossa. Ultrasonography showed partly cystic and solid area in mass arising from ovary. A tooth- like structure was also seen. Dermoid cyst was the diagnosis offered. Laparotomy was performed. Ovarian mass with hair, a tooth and putty-like material was present. Solid white area with thickened wall was found. Histopathology confirmed the findings of dermoid cyst and the thickened area showed squamous cell carcinoma with areas showing keratinous and giant cell reaction which was also seen at the periphery of tumor areas. Left ovary was normal and no deposits of tumor were seen. Postoperative period was uneventful.
Highlights
Benign cystic teratoma contains tissues that develop from ectoderm, endoderm and mesoderm in an organized manner
Preoperative assessment of the risk of malignancy is extremely difficult but very important for proper treatment planning and management. We report one such rare case of primary ovarian squamous cell carcinoma arising in a cystic teratoma, encountered in a peri-menopausal woman which seems to be worthy of review
On rare occasions (1-2%) the dermoids provide www.ssjournals.com a background for malignant transformation within components of the teratoma; the majority of such malignancies arising within an ovarian dermoid (80-90%) are squamous cell carcinomas[1]
Summary
Benign cystic teratoma (dermoid cyst) contains tissues that develop from ectoderm, endoderm and mesoderm in an organized manner. A tumor arising in young women are usually benign, but rarely may be associated with germ cell tumor or exhibit secondary malignancy after initial growth. Primary squamous cell carcinoma (SCC) of the ovary is extremely rare[1]. The de novo development of a primary squamous carcinoma, in an otherwise healthy ovary is an extremely rare occurrence[2]. Preoperative assessment of the risk of malignancy is extremely difficult but very important for proper treatment planning and management. We report one such rare case of primary ovarian squamous cell carcinoma arising in a cystic teratoma, encountered in a peri-menopausal woman which seems to be worthy of review. A brief review of literature with emphasis on factors which help in preoperative risk assessment is presented
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