Abstract
Specific autoantibodies are often reported as occurring in autoimmune diseases, with some autoantibodies believed to be myositis-related. These autoantibodies are placed into two groups according to their diagnostic accuracy: myositis-specific antibodies (MSAs) and myositis-associated antibodies (MAAs). Of the MSAs, anti-signal recognition particle (SRP) antibodies occur in idiopathic inflammatory myopathy (anti-SRP myopathy), an immune-mediated necrotizing myopathy. This case report concerns a 65-year-old Japanese man who was diagnosed as having anti-SRP myopathy associated with anti-Sjogren’s syndrome-related antigens A/Ro (SS-A/Ro) antibody. Given my experience with anti-SRP myopathy with typical clinical features and a coexistence with anti-SS-A/Ro antibody, a literature review to evaluate this autoantibody combination in inflammatory myopathy was performed. Coexistence of anti-SRP antibody with anti-SS-A/Ro antibody was not unique, but this combination may be not by chance but one subset occurring in inflammatory myopathy. It may mean that the disease condition is more severe and may be an indication of risk. Clarification of the MSA-MAA association in inflammatory myopathy may contribute to improved comprehensive clinical management and understanding of disease subsets. The severity of anti-SRP myopathy progresses in general, and intensive immunosuppressive maintenance treatments with human intravenous immunoglobulin will be required, as in the present case.
Published Version
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