Abstract
Three organic cocrystals namely, caffeine:p-formylphenoxyacetic acid [(caf)(p-fpaa)] (1) caffeine:o-formylphenoxyacetic acid monohydrate [(caf)(o-fpaa)]H2O (2) and caffeine:p-formylphenoxypropionic acid [(caf)(p-fppa)] (3) were synthesized and studied by FT-IR, NMR, and single crystal XRD studies. The crystal system of cocrystal [(caf)(p-fpaa)] (1) is monoclinic with space group P21/n and Z=16, that of cocrystal [(caf)(o-fpaa)]H2O (2) is triclinic with space group P−1 and Z=2, and that of cocrystal [(caf)(p-fppa)] (3) is monoclinic with space group P21/c and Z=4. The imidazole–carboxylic acid synthon is observed in all the three cocrystals. The intermolecular hydrogen bonds, OH···N and π–π interactions together play a major role in stabilizing the crystal structure of all the three cocrystals. The biological activities of crystals 1–3 were studied.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
