Abstract
Two organic cocrystals namely, caffeine:cinnamic acid [(caf)(ca)] (1) and caffeine:eosin dihydrate [(caf)(eos)]·2H2O (2) were synthesized and studied by FT-IR, TGA/DTA, and single crystal XRD. The crystal system of cocrystal 1 is triclinic with space group P-1 and Z=2 and that of cocrystal 2 is monoclinic with space group P21/C and Z=4. An imidazole–carboxylic acid synthon is observed in the cocrystal 1. The intermolecular hydrogen bond, O–H⋯N and π–π interactions play a major role in stabilizing 1 whereas the intermolecular hydrogen bonds, O–H⋯O, O–H⋯N, and intramolecular hydrogen bond, O–H⋯Br; along with π–π interactions together play a vital role in stabilizing the structure of 2. The antimicrobial- and DPPH radical scavenging activities of both the cocrystals were studied.
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