Abstract
[M(X)2(N,N/)2] (M = Co(II), Ni(II), Cu(II); X = N3−, SCN−; N,N/ = N-{(2-pyridyl) methyliden}-6-coumarin, a bidentate diimine pyridyl-N (N), imine-N (N/) chelator) have been characterized by different physicochemical data. The structural confirmation has been done for [Ni(N3)2(N,N/)2] by single crystal X-ray diffraction data. On considering the sequence of coordination of azide-N (N3−), pyridyl-N (N) and imine-N (N/) the structure of [Ni(N3)2(N,N/)2] follows cis-cis-cis-(ccc)-Ni(N3)2(N,N/)2] configuration. The complexes are paramagnetic and the EPR spectra of Cu(II) complexes provide information about hyperfine and super-hyperfine structures. The cyclic voltammogram shows M(II)/M(III), Cu(I)/Cu(II) and reductions of chelated diimine ligand. Only [Cu(N3)2(N,N/)2] (3) shows efficient catecholase activity (rate, 4.93 × 10−4 min−1) while [Cu(SCN)2(N,N/)2] (6) is very slow and other complexes are silent. The complexes show significant interaction with DNA and [Cu(N3)2(N,N/)2] (3) shows highest binding constant 5.58 × 105 (ΔG, −7.43 kcal mol−1) amongst these complexes.
Published Version
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