Abstract
Herein, we report a practical example of salicylaldehyde-based cobalt-catalyzed C−H deuteriomethoxylation of benzamides using deuterated methanol, facilitated by 8-aminoquinoline as a directing group. The salicylaldehyde-based cobalt catalyst is user-friendly, and the reaction exhibits broad functional group tolerance, accommodating benzene, heterocycles, and naphthalene rings. The synthetic utility of this methodology was demonstrated through a gram-scale reaction and the subsequent removal of the 8-aminoquinoline directing group to yield deuteriomethoxylated benzoic acid. Preliminary mechanistic studies suggest that C−H activation is not the rate-determining step of the reaction.
Published Version
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