Cobalt Ferrite MNPs: An Efficient and Robust Catalyst for Synthesis of 1,3,5‐Trisubstituted Pyrazolines

Abstract

AbstractNovel synthesis of 1,3,5‐trisubstituted‐2‐pyrazoline and its derivatives, showing broad spectrum of biological activities in wide range of scientific disciplines is designed via condensation of substituted chalcones and aryl hydrazine in presence of the magnetically separable cobalt ferrite nanoparticles (CoFe2O4 MNPs) to get aimed product with excellent yield in possibly shorter reaction time. Divers structural, morphological, and spectral analytical studies as X‐ray diffraction (XRD), scanning electron microscopy (SEM), and FTIR confirm the formation of CoFe2O4 nanoparticles. The synthesized compounds are characterized and confirmed by spectral analysis. The ambient reaction conditions, ease of purification of the products, and reusability of the catalyst up to five catalytic cycles with almost negligible decrement of catalytic activity making the current protocol benign and promising for its synthetic applications.