Synthesis and Biological Activity of Some Novel Phenyl Pyrazoline Derivatives

Abstract

A new series of 4-(4-hydroxyphenyl)-3-chloro-1-{4-(5-(substituted phenyl)-1-phenyl- 4,5- dihydro-pyrazol-3-yl)phenyl}azetidin-2-one were synthesized by reacting 3-chloro-1-{4-(3- (substituted-phenyl)prop-2-enoyl)phenyl}-4-(4-hydroxyphenyl)azetidin-2-one (0.01 M) and phenyl hydrazine (0.01 M) in presence of acetic acid (glacial). All these compounds were characterized by means of their IR, 1 H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method. 14-17 . In the present study, the reaction of 3- chloro-1-{4-(3-(substituted phenyl) prop-2-enoyl) phenyl}-4-(4-hydroxyphenyl) azetidin-2- one with phenyl hydrazine in presence of acetic acid (glacial) to form pyrazoline derivatives 4a-j (Scheme 1). The structures of the various synthesized compounds were assigned on the basis of IR, 1 H NMR spectral data and elemental analysis. These compounds were also screened for their antimicrobial activity.