Abstract
This work presents the effect of Co loading on the performance of CNR115 carbon-supported catalysts in the continuous-flow chemoselective hydrogenation of 2-methyl-2-pentenal for the obtention of 2-methylpentanal, an intermediate in the synthesis of the sedative drug meprobamate. The Co loading catalysts (2, 6, 10, and 14 wt.%) were characterized by Brunauer–Emmett–Teller (BET) surface area analysis, transmission electron microscopy (TEM), H2 temperature-programmed reduction (H2-TPR), temperature-programmed desorption of hydrogen (H2-TPD) analysis, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy for selected samples, and have been studied as hydrogenation catalysts at different pressure and temperature ranges. The results reveal that a certain amount of Co is necessary to achieve significant conversion values. However, excessive loading affects the morphological parameters, such as the surface area available for hydrogen adsorption and the particle size, preventing an increase in conversion, despite the increased presence of Co. Moreover, the larger particle size, caused by increasing the loading, alters the chemoselectivity, favouring the formation of 2-methyl-2-pentenol and, thus, decreasing the selectivity towards the desired product. The 6 wt.% Co-loaded material demonstrates the best catalytic performance, which is related to the formation of NPs with optimum size. Almost 100% selectivity towards 2-methylpentanal was obtained for the catalysts with lower Co loading (2 and 6 wt.%).
Highlights
In the last years, batch chemical processing has been moving towards continuous-flow systems [1]
It should be noted that the differences are minimal between 6 wt.% and 10 wt.% Co/CNR115
The slightly different shaped peak recorded for 2 wt.% Co/CNR115 may suggest that the structure of the active sites on the surface is different to the other samples, e.g., due to the highest metal dispersion (Table 2)
Summary
Batch chemical processing has been moving towards continuous-flow systems [1]. Continuous flow is the performance of chemical reactions in a flowing stream instead of a traditional batch. The benefit of continuous flow can be applied to heterogeneous catalytic hydrogenation This reaction is highly relevant in pharmaceutical, agrochemical, food, and fragrances industries [3]. This reaction is highly relevant in pharmaceutical, agrochemical, foof o15d, and fragrances industries [3]. The influence of four different Co loadings supported on commercial active carbon Norit CNR115 was analysed for the C=C chemoselective hydrogenation of an MPEA solution.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
