Co-administration of Adapalene loaded Nanostructured lipid carriers and Vitamin-E for management of acne

Abstract

The present work is aimed to design, develop and characterize a novel nanostructured lipid carrier system based formulation for selective and customized delivery of adapalene and Vit-E for effective management of acne vulgaris. Adapalene loaded nanostructured lipid carriers were developed by modified melt dispersion ultrasonication technique, followed by cooling and high speed mechanical stirring. Principally in the process glyceryl tristearin was used as solid lipid and oleic acid as liquid lipid, phospholipid 90G was used as surfactant and carbopol was used as gelling material. The prepared nanocarriers were characterized in terms of particle size, zeta potential, polydispersity index, entrapment efficiency, transmission electron microscopy (TEM) and in-vitro drug release study. The particle size of optimized carrier was reported as 219.8nm. TEM analysis was also performed to assure particle size and shape of carrier system. Entrapment efficiency of optimized formulation was above 87.4%. The drug release from carrier have shown dual biphasic release pattern firstly the drug release rate was rapid which showed initial burst release pattern and subsequently sustained release pattern was observed which is required in treatment of acne. Then prepared and optimized formulation was subjected to skin permeation study in male Wistar rats. Formulation was also characterized for skin distribution study, skin irritation study and stability study of gel. So it was concluded in our research that this novel carrier system having adapalene and Vit-E can be a very innovative alternate of conventional antiacne therapy. In our research, drug is localized in superficial skin layer and systemic penetration of drug was avoided. Further, concrete research can open new avenues in antiacne treatment.