Abstract
Esophageal cancer is the seventh most common cancer worldwide. It has a high mortality rate both due to its aggressive biological behavior and the delay in diagnosis due to its asymptomatic clinical course in initial phases. Epidermoid carcinoma and adenocarcinoma are the most common histological subtypes, with differences in both their epidemiology and natural history which have prognostic and treatment implications. There is an arsenal of additional tests for its proper diagnosis and staging. The multidisciplinary approach and incorporation of new therapeutic targets open up new perspectives for the treatment of this aggressive disease.
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