Abstract

A crystal structure is no longer conceived as a static entity; rather, it often mirrors crystallization pathways, linking crystal structures with a solution scenario. In this study, taking a clue from a previously reported ionic cocrystal structure, an in situ acetic acid-based catalytic protocol is developed for the N-acylation of amines using ester sources. In addition to better catalytic efficiency, this in situ approach was extended further to a mechanochemistry protocol in the context of a multicomponent reaction. This points towards a broader applicability of crystal structures that goes beyond the domain of structural chemistry and delves into catalysis and mechanosynthesis.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.