Abstract
Clueless with fewer cues from endothelin. Commentary: Venous endothelin guides sympathetic innervation of the developing mouse heart.
Highlights
Specialty section: This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Cell and Developmental
Likewise sympathetic innervation of the heart takes place during embryogenesis, with axons from the stellate ganglia, principally, following blood vessels to reach their target and make synapses; a phenomenon relying on the expression of nerve growth factor (NGF; Ieda et al, 2004)
The work by Manousiouthakis and collaborators exposes the clear coordination orchestrated by endothelin between the projections of the cardiac sympathetic innervation and cardiogenesis
Summary
Specialty section: This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Cell and Developmental. A commentary on Venous endothelin guides sympathetic innervation of the developing mouse heart by Manousiouthiakis, E., Mendez, M., Garner, M.C., Exertier, P., and Makita, T.
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