Abstract
Summary Gas gangrene antitoxin neutralized lethal doses (LD 50 ) of soluble preformed heat-labile toxin in loop fluid of dogs with experimental strangulation obstruction. A reconstruction experiment was employed to demonstrate that C. sordelli toxin was the only lethal agent in supernatant fractions of strangulation fluids from dogs and rabbits. Peritoneal fluid was not as heavily laden with bacteria as loop contents from the same animals. The viable bacterial content of strangulation fluids was greatly diminished after being frozen or refrigerated. Clostridial toxins, viable bacteria and endotoxins may each play a role in the toxicity of strangulation obstruction. Preformed clostridial exotoxins have now been demonstrated in strangulation obstruction in the rabbit, rat, guinea pig and dog.
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