Abstract
Strangulation obstruction was studied in 149 guinea pigs employing either the closed or open loop technic. Animals treated with saline solution subcutaneously and an intraluminal or intraperitoneal antibiotic (kanamycin) survived significantly longer than untreated control animals. A soluble, preformed, lethal toxin was demonstrated in strangulated intestinal contents, and was neutralized by clostridial gas gangrene antitoxin. Fluids from guinea pigs treated with kanamycin were not lethal. The occurrence of the lethal toxin was correlated with massive numbers of clostridia, and pointed to a role for preformed clostridial toxin in the lethality of strangulated loop fluids. The importance of bacterial factors in strangulation obstruction is again emphasized.
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