Close relationships between in vitro ADMET and DMPK research in pre-clinical drug discovery

Kin Tam

doi:10.5599/admet.1.1.1

Abstract

I have recently been invited to become an editor of a new open-access journal, ADMET & DMPK. I am honored to take up this exciting and challenging position. At first glance, the journal name is just a combination of two acronyms/disciplines in the pharmaceutical industry: ADMET (absorption, distribution, metabolism, excretion and toxicology) and DMPK (drug metabolism and pharmacokinetics), which sounds odd. Practically speaking, ADMET refers to a suite of in vitro assays that address various aspects of the pharmacokinetic performance of a drug, while DMPK more often refers to a drug’s in vivo pharmacokinetic performance. On thinking about it in more depth, it makes perfect sense to consider these two disciplines together, as a good DMPK profile of a drug candidate would be difficult to achieve without optimal ADMET properties, and both play an indispensable role in pre-clinical drug discovery. Here, I will share my views on the synergistic roles of these two disciplines, and how our new journal might help to foster the development of ADMET and DMPK.

Highlights

The discovery and development of a new candidate drug is a resource intensive and challenging process in the pharmaceutical industry
Speaking, ADMET refers to a suite of in vitro assays that address various aspects of the pharmacokinetic performance of a drug, while DMPK more often refers to a drug’s in vivo pharmacokinetic performance
On thinking about it in more depth, it makes perfect sense to consider these two disciplines together, as a good DMPK profile of a drug candidate would be difficult to achieve without optimal ADMET properties, and both play an indispensable role in pre-clinical drug discovery

Summary

Introduction

The discovery and development of a new candidate drug is a resource intensive and challenging process in the pharmaceutical industry. Close relationships between in vitro ADMET and DMPK research in pre-clinical drug discovery The journal name is just a combination of two acronyms/disciplines in the pharmaceutical industry: ADMET (absorption, distribution, metabolism, excretion and toxicology) and DMPK (drug metabolism and pharmacokinetics), which sounds odd.

Results

Conclusion