Abstract
Cloning of the Human C5a Anaphylatoxin Receptor, and More.
Highlights
Specialty section: This article was submitted to Chemoattractants, a section of the journal Frontiers in Immunology
Feltner and colleagues demonstrated that the FMLP, C5a, and LTB4 activities on rabbit neutrophils could be inhibited by pertussis toxin, indicating coupling to GTP binding proteins [3]
In order to enrich in C5a receptors, we took advantage of the fact that the receptors were induced by cyclic-AMP in U937 cells, and in retinoic acid differentiated human HL60 cells
Summary
Specialty section: This article was submitted to Chemoattractants, a section of the journal Frontiers in Immunology. Cloning of the human C5a anaphylatoxin receptor, and more. In the mid1986, a groundbreaking paper published in Nature announced the cloning of the beta-adrenergic receptor, and for the first time established seven transmembrane (7TM) G protein-coupled receptors as members of the rhodopsin superfamily [2].
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