Abstract
We have extensively characterized the structure and evolution of the adrenergic and muscarinic cholinergic receptors. This analysis has included studies with monoclonal antibodies, protein purification, target size analysis, gene cloning and sequencing and gene expression (1–7). Based upon the results of biochemical and immunological studies, we proposed that adrenergic and muscarinic cholinergic receptors are highly conserved proteins. This hypothesis has been confirmed by gene cloning experiments which have provided the primary structures of a number of adrenergic and muscarinic cholinergic receptors.
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