Abstract
Publisher Summary The responses of various effector organs to autonomic neurotransmitters are mediated by a number of structurally related receptors termed “adrenergic receptors” that respond to the catecholamines, epinephrine and norepinephrine, and muscarinic receptors that respond to acetylcholine. These receptors are widely distributed throughout the body. The pharmacological principles that underlie the function of adrenergic and muscarinic cholinergic receptors in the periphery are applicable in the central nervous system (CNS) as well. The application of molecular biology to the study of adrenergic and muscarinic cholinergic receptors has revealed that they are members of a much larger superfamily of G protein-coupled receptors that share a common mechanism of signal transduction. Understanding receptor diversity at a molecular level constitutes a major goal of receptor research as it would provide a framework for the design of subtype-specific pharmacologic agents.
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