Abstract
(1) The central “alpha adrenergic” agonist and antagonist clonidine (10 μg/kg) and piperoxane (1.0 and 2.5 mg/kg) were administered to nonhuman primates ( M. arctoides) in doses believed to increase or decrease activity at epinephrine-mediated synapses. (2) Clonidine, but not piperoxane or saline, produced a significant ( p < 0.05) rise in serum growth hormone (GH) levels at 30 min after the infusion. (3) Either pre-clonidine or post-clonidine administration of piperoxane blocked the clonidine-induced rise in GH levels. (4) These data support the hypothesis that the clonidine-induced increase in serum GH is mediated by alpha adrenergic receptors and suggest a role for epinephrine-mediated synapses in the stimulation of GH secretion.
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