Abstract
The use of blood liquid biopsy is increasingly being incorporated into the clinical setting of gastrointestinal cancers care. Clonal hematopoiesis (CH) occurs naturally as a result of the accumulation of somatic mutations and the clonal proliferation of hematopoietic stem cells with normal aging. The identification of CH-mutations has been described as a source of biological noise in blood liquid biopsy. Incorrect interpretation of CH events as cancer related can have a direct impact on cancer diagnosis and treatment. This review summarizes the current understanding of CH as a form of biological noise in blood liquid biopsy and the reported clinical significance of CH in patients with GI cancers.
Highlights
Gastrointestinal (GI) cancers contribute significantly to cancer-related burden [1]
We have summarized the current understanding of Clonal hematopoiesis (CH) as a form of biological noise in blood liquid biopsy and the reported clinical significance of CH in patients with GI cancers
Several studies have been performed to evaluate the identification of CH mutations in plasma and their impact on the interpretation of blood liquid biopsy results in patients with GI cancers (Table 1)
Summary
Gastrointestinal (GI) cancers contribute significantly to cancer-related burden [1]. Given the high mortality of GI cancers, the field of GI malignancies is in high need of a better understanding of tumor biology.Tissue biopsy is currently the gold standard for cancer diagnosis and allows tumor classification and molecular profiling. We have summarized the current understanding of CH as a form of biological noise in blood liquid biopsy and the reported clinical significance of CH in patients with GI cancers. Up to 15% of TP53 mutations found in lung cancer patients’ plasma cfDNA were found in white blood cells, indicating a CH origin.
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