Abstract
This chapter provides an overview of clofibrate. It discusses the nomenclature, formulae, molecular weight, and appearance, color, odor, and taste of clofibrate. Various physical properties—boiling range, density, refractive index, solubility, and spectral properties—are discussed. The synthesis, metabolism, and pharmacology of clofibrate are reviewed. Clofibrate reduces elevated triglyceride and cholesterol concentrations in serum. Various methods of analysis of clofibrate are discussed—elemental analysis, identification tests, purity tests, official methods, ultraviolet spectrophotometry, thin layer chromatography, thin layer-gas liquid chromatography, gas liquid chromatography, gas chromatography-mass spectrometry, and high-performance liquid chromatography. A spectrophotometric assay is described for the quantitation of clofibric acid in plasma and urine. This involves solvent extraction of clofibric acid from acidified plasma or urine and subsequent measurement of the UV absorbance at 226nm. Gas liquid chromatographic methods occupy a prominent position in the quantitation of clofibrate in drugs, tissues, and biological fluids.
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