Abstract
Clearance of plasma-triglycerides and activity of lipoprotein lipase in adipose tissue were studied in six hypertriglyceridæmic patients before and after a week of clofibrate therapy (2 g/day). Plasma-triglycerides decreased significantly from 6·85±1·1 to 2·66±0·29 mmol/l and triglyceride clearance increased significantly from 1·3±0·2 to 2·4±0·4%/min. There were concomitant significant increases in heparin-releasable lipoprotein lipase (95±16 to 181±34 nmol free fatty acids/106 cells/h) and in extractable lipase (88±14 to 179±28 nmol free fatty acids/106 cells/h). It is concluded that an important effect of clofibrate may be to increase the levels of adipose-tissue lipoprotein lipase and thereby improve the clearance of plasma-triglycerides.
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