CLİNİCAL AND MORPHOLOGİCAL PATTERNS OF ENDOCCRİNE-CELL CARSİNOMA OF UTERİ

Abstract

The relevance of the problem. The endicrine-cell carsinoma of corpus uteri and of the cervex uteri remains insufficiently studied, from clinical and proqnosis point of view insignificant group of malignant epithelial organ tumors. The purpose of the study. Taking into consideration all stated above, as the goal of current investigation has been appeared complex statistic, clinic, laboratory-instrumental and morphological study of this cancer with comparative analysis of results in different types of treatment, and also including progression and prognosis of the process. Material and methods. 405 cases of endocrine cell carcinoma of corpus uteri were identified within 2016- 2021. Complaints, anamnesis and clinical stages of the process approximately didn’t differ from the analogous groups of comparison of patient by the moment of appeal for the specialized aid. The obtained results and their discussion. It was determined that the fraquancy of countering of the endocrine cell carcinoma of corpus uteri is 26,1%, but the cancer of cervix uteri 12,7% from total number patients, respectively. It was proved that there exists the direct correlation between the frequency of endocrine cell carcinoma of corpus uteri and anatomical section of organ. In 56,0% od cases primary tumor origin is situated in lower segment of corpus, circus cervix or proximal part of cervical canal. “Carcinoids” and “Small cell homomorphous solid squamous cell and glandular carcinoids” were encountered most frequently among histotypes and the versions. Morphologically in tumor tissue were revealed mono and double specialized apudocytes, producing olygopeptides and amines with paraendocrine effects. Proceeding from secretory status of the endocrine tumor component were distinguished following clinical-morphological subgroups of endocrine cell carcinoma of corpus utseri: 1) with prevailing secretion of peptides (excluding the somatostatin); 2) with prevailing secretion of amines and somatostatin; 3) with similar secretion of peptides and amines. It was proved that, there is direct close correlation between prevailing hormonal status and clinical progression of endocrine-cell carcinoma of corpus uteri. Despite of somatostatin predominant secretion of oligopeptides by the tumor accelerates clinical progression, and brings to early and multidirectional metastases. On the contrary, with prevailing secretion of amines (serotonin, melatonin) and somatostatin the process doesn’t improving, and metastases, also, recurrences after radical therapy isn’t seen. It was revealed, that when choosing the tactic of radical treatment, side by side with the other factors, must be taken into consideration the hormonal status of endocrine-cell carcinoma of corpus uteri. High prevalence of secretion of oligopeptides in endocrine-cell carcinoma of corpus uteri can be useful in direct indication for choosing of complex or combinative treatment with necessary use radical surgical operation. Keywords: distinguished following clinical-morphological subgroups.